Education And Academic Experience£º
2016.6¡«Present Sichuan University, Professor
2014.10¡«2016.6 University of Michigan, Research Fellow
2012.07¡«2014.09 The Scripps Research Institute, Research Associate
2007.09¡«2012.07 Sichuan University, PhD; Asymmetric synthesis
2003.09¡«2007.07 Sichuan University, Bachelor; Organic chemistry
Publications:
1¡¢Ning Lei, Yanling Shen, Yujun Li, Pan Tao, Zishan Su and Ke Zheng* ¡°Electrochemical Iodoamination of Indoles Using Unactivated Amines¡± Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03158 //doi.org/10.1021/acs.orglett.0c03158
2¡¢Liquan Yang, Zhaoran Liu, Yujun Li, Ning Lei, Yanling Shen, and Ke Zheng* ¡°Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes¡± Org. Lett. 2019, 21, 7702?7707
3¡¢Dong Jing,# Cong Lu,# Zhuo Chen, Songyang Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng* ¡°Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex¡± Angew. Chem. Int. Ed. 2019, 58, 14666 ¨C14672.
4¡¢Cong Lu# Zhishan Su,# Dong Jing, Songyang Jin, Lijuan Xie, Liangrui, Li and Ke Zheng*
5¡¢Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng* ¡°A scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with RSH/ROH¡± Chem. Commun., 2019, 55, 4981-4984.
6¡¢Angelo Aguilar, # Ke Zheng, # et al. and Shaomeng Wang * ¡°Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction¡± J. Med. Chem. 2019, 62, 6015?6034.
7¡¢Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng* ¡°Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization¡± Eur. J. Org. Chem. 2019, 3649?3653.
8¡¢Ke Zheng, Xiaohua Liu, and Xiaoming Feng* ¡°Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles¡± Chem. Rev. 2018, 118, 7586?7656.
9¡¢Shilin Xu#, Angelo Aguilar#, Tianfeng Xu#, Ke Zheng#, et al. and Shaomeng Wang * ¡°Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein¨CProtein Interaction¡± Angew. Chem. Int. Ed. 2018, 57, 1601?1605.
10¡¢Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* ¡°Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors¡± ACS Med. Chem. Lett., 2015, 6, 413-418.
11¡¢Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V. LoGrasso,* and Yangbo Feng*¡°Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors¡± J. Med. Chem. 2015, 58(4), 1846-1861.
12¡¢Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* ¡°Design and Synthesis of Highly Potent and Selective JNK3 Inhibitors: SAR Studies on Aminopyrozal Derivatives¡± J. Med. Chem. 2014, 57, 10013-10030
13¡¢Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, and Xiaoming Feng* ¡°Completely OH-Selective FeCl3 Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans¡± J. Am. Chem. Soc. 2012, 134, 17564?17573.
14¡¢Ke Zheng, Lili Lin and Xiaoming Feng* ¡°Chiral N,N '-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate¡± Acta Chim. Sinica 2012, 70, 1785-1790.
15¡¢Ke Zheng, Chengkai Yin, Xiaohua Liu, and Xiaoming Feng* ¡°Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles¡± Angew. Chem. Int. Ed. 2011, 50, 2573.
16¡¢Ke Zheng, Xiaohua Liu, Jiannan Zhao, Yang Yang, Lili Lin and Xiaoming Feng* ¡°Highly Enantioselective Aza-Ene-Type Reaction Catalyzed by Chiral N,N¡¯-dioxide-nickel(II) Complex¡± Chem. Commun. 2010, 46, 3771¨C3773.
17¡¢Ke Zheng, Yang Yang, Jiannan Zhao, Chengkai Yin, Lili Lin, Xiaohua Liu and Xiaoming Feng*. ¡°Magnesium(II)-Catalyzed Asymmetric Ketone-Ene Reaction: Stereocontrolled Access to Enantioenriched Trifluoromethyl-Substituted Compounds¡± Chem. Eur. J. 2010, 16, 9969.
18¡¢Ke Zheng, Jian Shi, Xiaohua Liu, and Xiaoming Feng*. ¡°Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N¡¯-Dioxide -Nickel(II) Complex: Remarkably Broad Substrate Scope¡± J. Am. Chem. Soc. 2008, 130, 15770-15771.
19¡¢Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* ¡°Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N¡¯-Dioxide-In(III) Complexes¡± J. Org. Chem. 2007, 72, 8478-8483.
20¡¢Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* ¡°Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N¡¯-Dioxide-In(III) Complexes¡± J. Org. Chem. 2007, 72, 8478-8483.
21¡¢Y. Yan, K. Zheng, et al, Y. Feng* and P. LoGrasso*. ¡°Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors¡± J. Med. Chem. 2015, 58(4), 1846-1861.
22¡¢X. Liu, K. Zheng, and X. M. Feng. ¡°Advancements in the Catalytic Asymmetric Intermolecular Ene-Type Reactions¡± SYNTHESIS, 2014; 46: 2241-2257
23¡¢J. N. Zhao, K. Zheng, et al and X. M. Feng. ¡°Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N¡¯-Dioxide¨CNi(II) Complex¡± Synlett, 2011, 903-906.
24¡¢P. HaJeung; I. Sarah; H. Pamela; M. Rudy; K. Zheng, et al, Y. Feng and P. LoGrasso. ¡°Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles¡± Scientific reports 2015, 5, 8047
25¡¢K. Shen, X. H. Liu, K. Zheng, et al and X. M. Feng. ¡°Catalytic Asymmetric Synthesis of 3-(a-Hydroxy-b-carbonyl) Oxindoles by a Sc(III)-Catalyzed Direct Aldol-Type Reaction¡± Chem. Eur. J. 2010, 16, 3736-3742.
26¡¢J. Shi, M. Wang, L. He, K. Zheng, et al and X. M. Feng. ¡°Enantioselective Michael addition of malononitrile to chalcones catalyzed by a simple quinine-Al(OiPr)3 complex: a simple method for thesynthesis of a chiral 4H-pyran derivative¡± Chem. Commun. 2009, 45, 4711¨C4713.
B. Qin, X. H. Liu, J. Shi, K. Zheng, et al and X. M. Feng. ¡°Enantioselective Cyanosilylation of a,a-Dialkoxy Ketones Catalyzed by Proline-Derived in-Situ-Prepared N-Oxide as Bifunctional Organocatalys¡± J. Org. Chem. 2007, 72, 2374.
